Oral 5

Title Poster First Author Abstract or summary Type
A Multi-Centre, Randomised Controlled Trial Of A Group Psychological Intervention For Psychosis With Comorbid Cannabis Dependence Over The Early Course Of Illness Kevin Madigan

Background: Patients who experience the onset of psychotic illness with a comorbid diagnosis of cannabis dependence experience poor clinical outcomes. Few studies have identified interventions that reduce cannabis use and improve clinical outcome amongst this population. Aims We undertook a multi-centre, randomised controlled trial of a group psychological intervention for psychosis with comorbid cannabis dependence to establish any effect to reduce cannabis use and improve symptoms, global functioning, insight, attitudes to treatment and subjective quality of life.

Conference Presentations
Time Changes In Cannabis Use In A Cohort Of Patients With First Episode Psychosis And Association With Clinical And Social Outcome. A Five-Year Follow-Up Of The Opus Cohort Merete Nordentoft

The aim was to assess whether abuse of cannabis in patients with first episode psychosis influences the clinical and social outcome. Methods: A total of 547 patients with first episode schizophrenia spectrum disorder were included in the OPUS trial, and 301 patients participated in the five year follow-up. Information on use of cannabis, clinical and social factors and service use was collected at entry and after five years from clinical interviews with SCAN, SAPS and SANS.

Conference Presentations
The Complex Interplay Of Substance Use And Service Delivery: The Perspective Of Young People Treated For A First Episode Psychosis Suzanne Archie

Objective: It is important to listen to the voices of young people, who have had first-hand experiences with the healthcare system, in order to reform the system so services are more youth-friendly. The system may have even more difficulty engaging first episode psychosis youth who have had problems with substance use. In order to incorporate the perspective of these young people, qualitative methodologies may help researchers to better understand their viewpoint.

Conference Presentations
Capopus - Intervention Study For Cannabis Use Disorder In Psychosis Carsten Hjorthøj

Context: Cannabis abuse is highly prevalent in psychotic patients. Previous psychosocial interventions have shown little efficacy for reducing cannabis use, possibly owing to low sample size and risk of bias. Design Centrally randomised, observer-blinded, parallel-group clinical trial. Patients A referred sample of 103 patients with ICD-10 psychosis and cannabis-use disorder. Interventions Patients were randomised to six months of TAU (n=51) or TAU plus CapOpus (n=52), the latter consisting mainly of motivational interviewing and cognitive behaviour therapy.

Conference Presentations
Reduced Electrophysiological Response To Pleasant Images In Young Schizophrenia-Spectrum Patients: Association With Future Cannabis Use Clifford Cassidy

Background: multiple lines of evidence point to reward system dysfunction in schizophrenia-spectrum disorders (SSD) and substance-use disorders but there has been a lack of neurobiological research to test if blunted response to naturally reinforcing stimuli promotes substance use in SSD. Method: Response to emotional images and to visual cannabis cues was assessed in young SSD patients with (n = 20) and without (n = 12) cannabis use and controls with (n = 19) and without (n = 11) cannabis use.

Conference Presentations