Symposium

Title Poster First Author Abstract or summary Type
EARLY INTERVENTION IN PSYCHOSIS: A MAP OF LATIN AMERICA CLINICAL AND RESEARCH INITIATIVES Rodrigo Bressan

Objective: The presentation aims to review Latin America's Early Intervention Services (EIS) in psychosis, and to shed light onto their challenges and particularities. Method: An Internet-based search comprising medical societies websites, published articles, and major universities websites was conducted and the results were critically discussed. Results: Latin American countries are profoundly deficient in specialized EIS. Our research found 7 target services, among which 4 are based in urban areas of Brazil, inside tertiary hospitals or universities.

Conference Presentations
Development and implementation of the London Early detection And Prevention (LEAP) service in an inner London prison setting Lucia Valmaggia

In this talk we describe the development and implementation of LEAP. LEAP is an innovative service providing early detection and early intervention for emerging mental health problems within a prison setting.

Conference Presentations
Implementing At-Risk Mental State Services in a Japanese Clinical Setting Kazunori Matsumoto

Background: The concept of at-risk mental state (ARMS) is valuable for identifying individuals in a putative prodromal state of psychosis and for reducing conversion risk. However, since most evidence is derived from longitudinal observations in Western countries, observations from the rest of the world are imperative if the concept is to be generalized to various clinical settings.Methods: A naturalistic longitudinal study was conducted at a specialized early psychosis clinic at a university hospital in Sendai, Japan.

Conference Presentations
TRIPP: TRauma-Informed Psychotherapy for Psychosis Sarah Bendall

Traumatic experiences, and their symptomatic and functional consequences, are becoming increasingly important in the treatment of first episode psychosis (FEP). Our recent data shows that post-traumatic stress disorder (PTSD) in FEP is common and results from both childhood trauma and acute psychosis (47% and 39% respectively). Thus far, trials of the treatment of trauma symptoms in psychosis have focussed on PTSD symptoms.

Conference Presentations
Cognitive pathway between trauma and psychosis Emmanuelle Peter

Cognitive models of psychosis suggest that (1) appraisals are key in determining the transition from benign anomalous experience to psychotic symptoms, and (2) trauma may be one of the predisposing factors to psychosis, which is increasingly supported by empirical evidence (Varese et al, 2012). However it remains unclear whether trauma predisposes to the development of anomalous experiences, or to the pathogenic appraisals which transform them into psychotic symptoms.

Conference Presentations
The role of childhood abuse in the course and outcome of psychotic disorders over 10 years. Helen L Fisher

Increasing evidence suggests that exposure to traumatic events in childhood is linked to the emergence of psychotic disorders in adulthood. However, the impact of childhood trauma on the longer-term outcomes of psychosis is largely unknown. Initial research suggests that early trauma is associated with worse clinical and functional outcomes amongst those with psychotic disorders. However, these studies suffer from a range of methodological limitations.

Conference Presentations
Long-term outcome following early dose-reduction of antipsychotics in remitted first episode psychosis Lex Wunderink

Objective Comparing 7-year outcome of early antipsychotic dose-reduction/discontinuation (DR) with maintenance treatment (MT) on remission, relapse and recovery in remitted first episode psychosis (FEP).Method FEP patients (N=128) symptomatically remitted for 6m during their first treatment year who completed an 18 months trial comparing MT and DR were followed-up at 7 years. Symptomatic remission criteria were adopted from Andreasen et al., functional remission criteria were based on a functioning scale. Recovery was defined as meeting both criteria sets.

Conference Presentations
The relation between antipsychotic medication history and ten-year outcome in first episode psychosis Ingrid Melle

ObjectiveAntipsychotic medication has significant clinical effect in reducing psychotic symptoms and preventing relapse in psychotic disorders. Many are however negative to long-term use due to side-effects and clinical experience indicates that some patients manage well without medication in the longer term. Methods281 patients with first-episode, schizophrenia spectrum disorders entered a medication algorithm advising 2 years continuous medication. Patients were followed from first week of treatment with re-evaluations after 3 months, 1, 2, 5 and 10 years.

Conference Presentations
Developmental trajectories and psychopathology in young relatives at risk for schizophrenia Matcheri S Keshavan

Objectives. A great deal of research has focused on identifying predictors and developing early interventions for individuals with psychotic disorders such as schizophrenia. While the relationships between early psychopathology, neurocognitive and social deficits and later emergence of psychosis have been studied for some time, the temporal evolution of psychopathology and its neurodevelopmental parallels in individuals at high risk (HR) for schizophrenia is less well characterized.

Conference Presentations
Cognitive change is related to brain loss in the early phases of schizophrenia Rene S Kahn

Background. There is consistent evidence for cognitive changes prior to the onset of psychosis in schizophrenia. Also, progressive brain changes during the course of the disease have consistently been shown, but it has not been studied whether the two phenomena are related.Method. A total of 78 first-episode schizophrenia patients and 113 age-matched healthy controls were tested twice with a three year interval. IQ and 1.5T sMRI were obtained at both time points.

Conference Presentations

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