Oral

Title Poster First Author Abstract or summary Type
Dissecting dopamine, salience and the risk of psychosis Toby Winton-Brown

This study unpacks the concept of 'salience as invoked by Kapur and others in linking dopamine dysregulation to psychotic symptoms. Rather than relying on one-dimensional reward based conception of salience that has dominated studies so far it develops a multidimensional view. It sets out to then test this using fMRI and PET scanning in unmedicated subjects at high clinical risk for psychosis (UHR) in the neural setting of the MAM animal model of schizophrenia, that predicts abnormal hippocampal outputs drive striatal dopamine dysfunction in psychosis.

Conference Presentations
Effect of childhood adversity on brain dopamine function in adulthood Alice Egerton

Traumatic experiences during childhood increase the risk of psychosis illness. Abnormal dopamine function is a key feature of psychotic disorders and a plausible mediator of an effect of childhood stressors on risk of later illness. This study investigated whether, in young healthy adults and in those at clinical high risk of psychosis, experience of childhood adversity was associated increased presynaptic dopamine function in the striatum.

Conference Presentations
Psychotic reactivity to daily life stress and the dopamine system: a study combining experience sampling and [18F]fallypride positron emission tomography. Inez Myin-Germeys

Background: Stressful life events increase the risk for psychosis and daily life stress drives moment-to-moment variation in psychotic intensity. Positron emission tomography (PET) studies suggest that prefrontal DAergic activity mediates the behavioral response to an experimental stressor. It is not known how alterations in this DAergic response, associated with psychosis, relate to real life stress responses in momentary assessment studies.

Conference Presentations
Idiopathic carbonyl stress in a subpopulation of schizophrenia Makotoi Ara

Evidence based on biological treatment and psychosocial support is essential to achieve and maintain a recovery for patients with schizophrenia. Studies have attempted to clarify the underlying disease mechanisms, however, the main cause and pathophysiology of schizophrenia remains unclear. Especially, heterogeneity in schizophrenia makes the search for molecular mechanisms much more difficult due to biochemical differences, variability across clinical symptoms, courses of illness, presence of risk factors and treatment responses.

Conference Presentations
Translational psychiatric research focusing on microglia – Does microglial modulation prevent psychosis? Takahiro Kato

Neurons and synapses have long been the dominant focus of neuroscience, thus the pathophysiology of neuropsychiatric disorders including schizophrenia has come to be understood within the neuronal doctrine. Recently, glial functions have been gradually investigated, and increasing evidence has suggested that glial cells including astrocytes, oligodendrocytes and microglia perform important roles in various brain functions.

Conference Presentations
Anterior Cingulate Cortex Abnormalities in Postpartum Psychosis. A structural MRI study. montserrat Fuste

Introduction: Postpartum Psychosis (PP) is the most severe psychiatric disorder associated with childbirth. The risk is very high in women with bipolar disorder. Unfortunately, the neurobiological basis of PP remains poorly understood and no previous study has evaluated brain structure in women at risk of, or with, PP. The aims of the study were: 1) Examine brain structural differences in women that develop PP episode compared to the ones that dont develop PP and healthy controls.

Conference Presentations
White matter integrity and cortisol levels in relation to treatment response in first-episode psychosis Tiago Reis Marques

Introduction: Previous studies have suggested that patients with first-episode of psychosis who show poor response to antipsychotic treatment have significantly impaired WM microstructure when compared to Responders. More recently, it as also been showed that baseline cortisol levels could also predict clinical outcome in first-episode psychosis. As the HPA axis is also known to indirectly affect white matter, is it possible to speculate that patient _s ability to respond to treatment is mediated through the effect of cortisol in white matter.

Conference Presentations
Predictors of caregiver distress in first-episode psychosis: subjective appraisal and expressed emotion Jens Einar Jansen

Background: Caregivers of persons with first-episode psychosis (FEP) often report high levels of distress. Preventing long-term or chronic distress within the whole family is an important focus of early intervention for psychosis. However, little is known about the psychological factors involved. Aims: To examine the impact of subjective appraisals and expressed emotion on caregiver distress in FEP.

Conference Presentations
Debate: Early Intervention for all mental disorders in all age groups would compromise the gains of decades of EI Psychosis Teams Peter Byrne

Early Intervention (EI) for young people with psychosis has become the gold standard. Generic community mental health services have too many other demands made of them to deliver specialist EI to this or other groups. They provide lifetime care to people with severe mental disorders (SMI) and are the gatekeepers for new onset disorders, provided patients' symptoms reach the threshold of severity and duration. Lowering this threshold or holding cases that may not develop SMI would overwhelm services so that no group would receive adequate levels of care.

Conference Presentations
Challenges to Recovery Following Early Psychosis: Implications of Recovery Rate and Timing W Joy Maddigan

The early psychosis movement is founded on an indicated prevention framework that has early illness identification and timely recovery as its driving force. This study advances understanding of recovery by examining the recovery status of individuals who participated in a three-year early psychosis program. This prospective cohort study of 260 individuals is one strand of a mixed methods investigation that explored recovery outcomes and experiences over a nine-year period (2001-2009). Two operational measures were used to explore the rate and timing of recovery within the cohort:1.

Conference Presentations

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