Studying Heart Arrhythmias in Relation to Psychosis (SHARP). Increased prevalence of suspect Brugada ECG in recent onset schizophrenia.

Presentation First Author: 
Arjen Sutterland

Introduction: Schizophrenia is associated with an increased risk of sudden cardiac death, traditionally attributed to prolonged QTc interval and cardiovascular risk factors such as metabolic syndrome. However, defective ion channels are also implicated in schizophrenia. This applies as well for Brugada syndrome (BrS), a rare hereditary cardiac disorder associated with an increased risk of cardiac arrhythmias, which can been provoked by various drugs, including psychotropic. Methods: 273 subjects with recent onset schizophrenia, admitted between 2006 and 2012 and 321 healthy controls underwent an ECG. All persons who had an ECG suspect for BrS were asked to receive a provocation test to diagnose/exclude BrS. We checked whether patients had deceased during follow-up. Results: 20/273 patients (7.3%) and 5/321 healthy controls (1.5%) showed a suspect ECG for BrS, yielding a Relative risk (RR) of 5,0 (p

Conference Name: 
Presentation Date: 
January, 2015
Additional Authors: 
Marieke Blom - Lieuwe de Haan - Hanno Tan
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