Reducing DUP in Amsterdam: results from the top trial

Presentation First Author: 
Don Linszen

Background: International early detection programs aiming to reduce the duration of untreated psychosis (DUP) show diverging effects resulting in identifying patients with shorter DUP, no effect and a long DUP. Methods: To examine the effects on the DUP for first-episode patients in Amsterdam as catchment area through the introduction of an early detection program (TOP), compared with historical cohorts in Amsterdam and Rotterdam without a TOP program. Consecutive recruited patients with a DSM-IV diagnosis of a first non-affective psychotic episode coming for first treatment in the health care areas between 2008 and 2010 were assessed with the Nottingham Onset Scale. Results: Preliminary findings of the effects of TOP in Amsterdam compared with the historical cohort showed a reduction of the median DUP from 16.5 to 13 weeks (Mann-Whitney p: 0.68). The DUP of historical cohort in Rotterdam without TOP appeared to be 6.5 weeks. Conclusion: In contrast with the TIPS study we did not find any reduction in DUP in patients recruited following the TOP program initiative. These findings are in agreement with the PEPP study, Canada. The relative short median DUP of the historical Rotterdam cohort may be due selection bias.

Conference Name: 
Presentation Date: 
January, 2013
Additional Authors: 
Don Linszen, Bauke Sterk, Liewe De Haan
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