Reduced rostral prefrontal cortex activity is associated with poor functional outcome in ultra-high risk and first-episode psychosis

Presentation First Author: 
Shinsuke Koike

Longitudinal clinical investigations and biological measurements for psychosis have enabled us to clarify not only progressive brain volumetric and functional changes but also the alternations of developmental pathways based on gene–environment interaction model. However, these studies have little contribution to clinical decisions on differential diagnosis and therapeutic choices. Near-infrared spectroscopy (NIRS) is a relatively small instrument with little noise that can easily and noninvasively measure hemoglobin changes over the surface of the cortex. NIRS instruments are easily moved including clinics and care units, and therefore, a candidate for clinical use in psychiatry. Our previous NIRS studies demonstrated that patients with stable chronic schizophrenia showed impaired activity and characteristic wave form patterns over the prefrontal cortical regions during a letter version of verbal fluency task, and that the activity in the rostral part of the prefrontal cortex was associated with the patients present symptoms. A cross-sectional study that focused on four different clinical stages of psychosis (controls, ultra-high risk, first-episode psychosis, and chronic schizophrenia) indicated varying activity patterns for different prefrontal cortical subregions. In this session, we will show the results of longitudinal investigation to elucidate whether (1) NIRS signals in the PFC predict the future and/or present clinical outcome and (2) the longitudinal trajectory of NIRS signal changes from the first-episode to chronic stages.

Conference Name: 
Presentation Date: 
January, 2015
Additional Authors: 
Yoshihiro Satomura - Yukika Nishimura - Ryu Takizawa - Kiyoto Kasai
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