Phase-specific cognitive remediation in the early course of schizophrenia

 
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Presentation First Author: 
Takahiro Nemoto
Abstract: 

Introduction: Although there is strong evidence that cognitive remediation is effective in chronic schizophrenia, there is little evidence about its efficacy in the early course of schizophrenia. The aims of this study were to demonstrate the usefulness of cognitive remediation and its effective methods in patients with early schizophrenia. Methods: Ninety-four outpatients (50 men, 44 women) with one of three conditions (schizophrenia in the critical period (within 5 years of the onset), chronic schizophrenia, or at-risk mental state for psychosis) were recruited. They were randomly assigned to either a cognitive training program for divergent thinking (DT) or a cognitive training program for convergent thinking (CT). Both training programs were administered as homework for 24 weeks. The patients were followed-up for a year. Clinical assessments and neurocognitive tests were administered every 3 months. The protocol of the study was approved by the institutional review board. Results: On the whole, participants who received the DT had significantly greater improvements in cognitive function and social functioning compared with participants who received the CT. In patients with schizophrenia in the critical period, participants who received the DT had significantly greater improvements in social functioning and a trend of improvements in symptoms and cognitive function compared with participants who received the CT. On the other hand, participants who received the CT had greater improvements in global functioning (clinical and social combined) in chronic schizophrenia. Discussion: The results suggest that phase-specific approaches are essential to cognitive remediation in schizophrenia.

Conference Name: 
Presentation Date: 
January, 2015
Additional Authors: 
Kiyoaki Takeshi - Hidehito Niimura - Miki Tobe - Ryosuke Ito - Hiroko Saito - Noriyuki Abe - Naohisa Tsujino - Kei Sakuma - Masafumi Mizuno
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