Non-remission of positive symptoms and functional recovery in first-episode psychosis

Presentation First Author: 
Swapna Verma

Objective: The aim of the study was to examine the rates and significant predictors of non-remission of positive symptoms in FEP and to evaluate the impact of non-remission on functional recovery. Methods: All consecutive patients with FEP presenting to the Singapore Early Psychosis Intervention Programme (EPIP) from 2001 to 2008 were recruited for the study. We used a priori criteria to define non-remission i.e. scores of ≥ 4 on at least one of the PANSS positive items (items 1, 3, 5, or 6) or general subscale item 9 measured at baseline, 3, 6, 12, and 24 months, persisting over a period of at least 6 months. Simple and multiple logistic regressions were performed to explore significant factors associated with non-remission. Results: There were 700 patients, 337 (48.1%) of whom were males with mean (SD) age of 28 years (6.4) and mean DUP of 16.6 weeks (28.9). At month 3, 12% (n=84) were still experiencing positive psychotic symptoms. This number declined to 3.1% (n=22) at month 6 and 0.4% (n=3) at years 1 and 2. 67 (9.6%) patients had continuous psychotic symptoms for at least 6 months and were considered non-remitters. We found that DUP was significantly associated with non-remission (OR 1.01; 95%CI, 1.0001-1.014, p value

Conference Name: 
Presentation Date: 
January, 2015
Additional Authors: 
Edimansyah Abdin - Mythily Subramaniam - Lye Yin Poon
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