Neurocognitive Functioning for Youth at Clinical High Risk of Developing Psychosis in NAPLS-2

Presentation First Author: 
Larry J. Seidman

Background: Neurocognitive impairment is common in youth at clinical high risk (CHR) for psychosis. However, the roles of medications and age have not been systematically addressed. We examined neurocognition in CHR individuals who transitioned to psychosis (CHR-T, n=41) vs. those who didnt (CHR-NT, n=286), based on the first half of the NAPLS-2 study. Methods: The sample consisted of baseline testing from 360 CHR individuals (n=327 tested) and 180 healthy controls (HC, n=177 tested), who had reached the 24 month follow-up. CHR status was determined with the Structured Interview of Prodromal Syndromes. A battery of 19 neurocognitive tests was administered. Factor analysis (FA) yielded 4 factors: Visual-Spatial, Attention - Working Memory, Verbal, and Declarative Memory. Smell identification and auditory perceptual (Babble) tests did not load in the FA but were also analyzed. Results: MANOVA was highly significant for the 4 factors and 19 individual measures (p

Conference Name: 
Presentation Date: 
January, 2015
Additional Authors: 
Daniel Shapiro - William S. Stone - Jean Addington - Carrie Bearden - Kristen S. Cadenhead - Tyrone Cannon - Barbara A. Cornblatt - Daniel H. Mathalon - Diana O. Perkins - Elaine F. Walker - Scott W. Woods
See other presentations in this session: