Neurocognitive and social cognitive performances in people at clinical high risk for psychosis: a 2-year follow-up study

Presentation First Author: 
Jun Soo Kwon

Background: Recently, neurocognitive and social cognitive dysfunctions are frequently reported in individuals at clinical high risk (CHR) for psychosis. However, longitudinal research is needed to confirm whether this is a specific marker for the transit to psychosis and remit from initial high risk state.Method: Seventy-five CHR subjects and 61 healthy controls were recruited, and their neurocognitive and theory of mind task performances were assessed. CHR subjects were divided into converter, remitter, and non-remitter groups according to their clinical state during a 12 to 24 follow-up.Results: At baseline, we found that the neurocognitive performances including executive functions, attention, verbal memory, verbal fluency, visual memory were significantly differences among the group. On the other hand, converters showed significantly reduced performances in theory of mind task compared with another groups, however, there were no significant difference among the remitter, non-remitter, and healthy controls. In longitudinally, we found that performance on semantic fluency was significantly improved in remitters but declined in non-remitters over the 2-year follow-up. However, there was no significant difference in theory of mind task performances between the groups during the follow-up period.Conclusion: We suggest that the social cognitive deficits could be a specific marker for vulnerability for psychosis, while semantic fluency is associated with conversion to psychosis or continuing clinical high risk state.

Conference Name: 
Presentation Date: 
January, 2015
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