Neurobiological Correlates of Basic Self-Disturbances in subjects at Clinical High Risk for Psychosis

Presentation First Author: 
Ilaria Bonoldi

Basic self-disturbances (BSD), (anomalies of the pre-reflective sense of first-person perspective), are core features of the schizophrenic spectrum disorders and distinctive clinical characteristics of subjects at Clinical High Risk for psychosis (HR). However their neurobiological correlates remain unknown, undermining their validity as clinical construct. The current available literature indicates that cortical midline structures (CMS), particularly medial prefrontal cortex, precuneus, anterior and posterior cingulate gyrus, together with inferior parietal and medial temporal areas, particularly the amygdalar and hippocampal regions, may be implicated in the neurobiological substrates of the basic self. Preliminary results from an ongoing study, conducted at the Institute of Psychiatry in London, investigating the relationship between BSD and HR neurobiology will be presented. 30 HR subjects (27 antipsychotics-naïve) and 20 healthy controls (HC) have been assessed with the 57-items semi-structured interview Examination of Anomalous Self-Experience-EASE, lasting 134 min (SD=40) in HR and 58 min (SD=10) in HC. Despite high variability in the HR group, the overall EASE score was higher (t-test

Conference Name: 
Presentation Date: 
January, 2015
Additional Authors: 
Luis Madeira - Paul Allen - Stefania Tognin - Matilda Azis - Beverly Quinn - Gemma Modinos - Matthijs Bossong - Jesus Perez - Oliver Howes - Paolo Fusar Poli - Philip McGuire
See other presentations in this session: