Longitudinal follow-up of screening for clinical-high-risk for psychosis with the prodromal questionnaire, brief version (pq-b)

Presentation First Author: 
Rachel Loewy

In a series of publications, we described the development of the Prodromal Questionnaire (PQ), a self-report screen for clinical high risk (CHR) for psychosis, and a brief version of the measure, the PQ-B. To date, we have reported primarily on the concurrent validity of the measure by comparing it to diagnoses on the Structured Interview for Prodromal Syndromes/Scale of Prodromal Symptoms (SIPS/SOPS). In the current and ongoing study, we present data on a new sample of over 100 adolescents and young adults who presented consecutively to one of two CHR research clinics at the University of California Los Angeles and San Francisco. Participants completed the PQ-B and SIPS/SOPS at baseline. Those diagnosed with CHR syndromes on the SIPS were followed clinically every 6 months for 24 months. The previously-defined distress cutoff score of 6+ on the PQ-B identified individuals with SIPS diagnoses of CHR/psychotic syndrome versus no SIPS diagnosis with slightly greater sensitivity and slightly lower specificity than in the original sample; a higher cutoff score performed with even better all-around accuracy. A greater proportion of CHRs with PQ-B scores above the cutoff developed full psychotic disorders by 12-month follow-up, compared to CHRs with low PQ-B scores. Although we do not have follow-up data on high and low PQ-B scorers who did not meet SIPS CHR criteria at baseline, these results suggest that the two-stage screening process of high PQ-B scores and SIPS CHR diagnoses does accurately identify a group of young people at imminent risk for psychosis.

Conference Name: 
Presentation Date: 
January, 2013
Additional Authors: 
Rachel Loewy, Rahel Pearson, Carrie Bearden, Jamie Zinberg, Sophia Vinogradov, Tyronne Cannon
See other presentations in this session: