Long-term follow-up of the tips early detection in psychosis study: effects on ten-year outcome

Presentation First Author: 
Wenche ten Velden Hegelstad

Objective: Early detection in first episode psychosis confers advantages for negative, cognitive and depressive symptoms at 1, 2 and 5 years follow-up. Longitudinal effects are unknown. The objective of this study has been to investigate differences in symptoms and recovery at 10 years between an area with, and an area without early detection. Methods: 281 (early detection: 141, no-early detection: 140) patients aged 18-65 with a first episode of non-affective psychosis were included between 1997 and 2001. Of these, 101 early detection and 73 no-early detection patients were followed up at 10 years and compared on symptom levels (PANSS) and recovery. Recovery combined standardized remission criteria and functional outcome. Results: A significantly higher percentage of early detection patients compared to no-early detection patients had recovered at 10 years. This held true despite more severely ill patients dropping out of the study in the no-early detection area. Except for higher levels of excitative symptoms in the early detection area, there were no symptom differences between the groups. Early detection recovery rates were higher largely because of higher employment rates for patients in this group. Conclusions: Early detection of first episode psychosis appears to increase the chance of milder deficit formations and superior functioning. The mechanisms by which this strategy improves the long-term prognosis of psychosis remain speculative. Nevertheless, our findings over ten years may indicate that a prognositv link exists between timing of intervention and outcome that deserves further study.

Conference Name: 
Presentation Date: 
January, 2013
Additional Authors: 
Wenche ten Velden Hegelstad, Tor K. Larsen, Julie Evensen, Svein Friis, Ulrick Haahr, Inge Joa, Jan O. Johannesen, Johannes Langeveld, Ingrid Melle, Stein Opjordsmoen, Jan Ivar Rossberg, Thomas McGlashan
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