Investigating developmental trajectory of self-regulation and vulnerability to psychosis by neuroimaging: subsample of Tokyo Teen Cohort study

Presentation First Author: 
Naohiro Okada

Tokyo Teen Cohort (TTC) study is a large-scale general population-based survey to elucidate puberty development during adolescence, especially the acquisition process of self-regulation and willingness to challenge, through focusing on interaction between bio, psycho, and social factors. Participants include 5,000 10-year-old children and their carers living in Tokyo Metropolitan area. Information about characteristics of daily life, family form, physical and mental health, and puberty onset as well as about self-regulation and psychological well-being is acquired from participants. Furthermore, we conduct a biological subsample study following as an extension of TTC study. In the subsample study, we intend to collect hormone and DNA derived from saliva and brain structural and functional MRI images from 200 children who took part in TTC study, to explore what facilitates or obstructs successful development of mental health during adolescence at the hormonal, genomic, and neural level. Little is known about the pathology involved in the preclinical stage of early psychosis. In adolescence young people acquire various advanced mental functions such as self-regulation and it is speculated that disturbance of these functions may enhance vulnerability to the onset of early psychosis. In this session we will illustrate the result of our MRI study on neural substrates of self-regulation in adolescence, which might afford better insight into pathology of vulnerability to psychosis or potential pathological changes preceding the onset of psychosis. Then we will discuss the validity of our current results and the future directions.

Conference Name: 
Presentation Date: 
January, 2015
Additional Authors: 
Noriaki Yahata -Kiyoto Kasai
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