The fractional anisotropy of the white matter in an at-risk mental state for psychosis: the tract specific analysis

Presentation First Author: 
Junichi Saito

Introduction: Examining the fractional anisotropy (FA) values as an indicator of integration of white matter in individuals with an at-risk mental state (ARMS) for psychosis is important to reveal the vulnerability factors and pathogenic mechanisms. Methods: Thirty-one right-handed ARMS patients were scanned using magnetic resonance imaging (MRI) to acquire diffusion tensor imaging (DTI) images at baseline and at 52 weeks. Sixteen right-handed healthy controls (HCs) underwent MRI scanning at baseline. The DTI results were analyzed using a Tract Specific Analysis (TSA) to measure white matter integrity as the FA value. Results: The FA values of the ARMS patients were significantly lower than the values of the HCs in the right cingulum and the right and left uncinate fasciculus at baseline, and in the right uncinate fasciculus at 52 weeks. However, there were no longitudinal differences between the FA values in the cingulum and the uncinate fasciculus of the patients, respectively. Discussion: In schizophrenia patients, it is known that the FA values are significantly lower than healthy controls in the cingulum and the uncinate fasciculus. These regions have been suggested to be associated with social and cognitive functions. In this study, we found that the FA values in these regions also decreased in ARMS patients. The results suggested that the integration abnormality in these regions had been appearing under the process to psychosis in the early stage.

Conference Name: 
Presentation Date: 
January, 2015
Additional Authors: 
Takahiro Nemoto - Masaaki Hori - Naoyuki Katagiri - Naohisa Tsujino - Tomoyuki Funatogawa - Kiyoaki Takeshi - Masafumi Mizuno
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