Childhood Neurodevelopmental Disorders, IQ and Subsequent Risk of Psychotic Experiences in the ALSPAC Birth Cohort

Presentation First Author: 
Golam Khandaker

Background: Schizophrenia has a neurodevelopmental component to its origin, and may share overlapping pathogenic mechanisms with childhood neurodevelopmental disorders (ND). Yet longitudinal studies of psychotic outcomes among individuals with ND are limited. We report a population-based prospective study of six common childhood ND, subsequent neurocognitive performance and the risk of psychotic experiences (PE) in early-adolescence. Methods: PE were assessed by semi-structured interviews at age 13 years. IQ and working memory were measured between ages 9 and 11 years. The presence of six neurodevelopmental disorders (autism spectrum, dyslexia, dyspraxia, dysgraphia, dysorthographia, dyscalculia) was determined from parent-completed questionnaire at age 9 years. Linear regression calculated mean difference in cognitive scores between those with and without ND. The association between ND and PE was expressed as odds ratio (OR); effects of cognitive deficits were examined. Potential confounders included age, gender, social class, ethnicity and maternal education. Results: Out of 8,220 children, 487 (5.9%) were reported to have ND at age 9 years. Children with, compared with those without ND performed worse on all cognitive measures; adjusted mean difference in total IQ 6.8 (95% CI 5.0-8.7). The association between total IQ and ND was linear (p

Conference Name: 
Presentation Date: 
January, 2015
Additional Authors: 
Jan Stochl - Stanley Zammit - Glyn Lewis - Peter Jones
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