Assessment of Self Disturbances in High Risk Adolescents and Clinical Controls: Preliminary Findings from a Multi-Center Psychosis Prevention Program

Presentation First Author: 
N Lo Cascio

Background Two sets of high risk criteria are commonly used in the early detection of psychosis: the Ultra-High Risk (UHR) and the Cognitive Disturbances (COGDIS) criteria. Besides these, Parnas and colleagues have developed the Examination of Anomalous Self-Experience (EASE) for the assessment of Self-Disturbances (SD), which are considered a specific subjective phenotype of schizophrenia. Methods This is a multi-center study. The sample consists to date of 79 non-psychotic adolescents aged 14-18. The following instruments were administered: 1) The Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version; 2) The Structured Interview for Prodromal Syndromes; 3) The Schizophrenia Proneness Instrument – Child and Youth version; 4) The EASE; 5) The Global Functioning Role and Social Scales. Data were analyzed using non-parametric tests. Results 48 subjects were classified at High Risk (HR) for psychosis, according to UHR or COGDIS criteria; 31 subjects were classified as clinical controls (CC). Compared to CC, HR had higher total EASE scores (10.1 ± 4.8 vs. 5.6 ± 4.1, p = 0.001), as well as higher domain scores of Cognition and Stream of Consciousness (4.3 ± 2.5 vs. 2.1 ± 2.0, p = 0.001), Self-Awareness (4.1 ± 2.8 vs. 2.8 ± 2.3, p = 0.040) and Presence and Existential Reorientation (0.6 ± 1.0 vs. 0.1 ± 0.4, p = 0.009). No correlations were found between SD and Global Functioning scores. Discussion SD seem to be confirmed as a specific subjective phenotype of schizophrenia-spectrum disorders. Thus, the EASE may be a valid early detection instrument.

Conference Name: 
Presentation Date: 
January, 2015
Additional Authors: 
E Monducci - G Colafrancesco - M Armando - C Dario - M Patanè - N Girardi - C Battaglia - C Margarita - R Saba - A Raballo - P Fiori Nastro
See other presentations in this session: