IEPA 2014

Title Poster First Author Abstract or summary Type
Phase-specific cognitive remediation in the early course of schizophrenia Takahiro Nemoto

Introduction: Although there is strong evidence that cognitive remediation is effective in chronic schizophrenia, there is little evidence about its efficacy in the early course of schizophrenia. The aims of this study were to demonstrate the usefulness of cognitive remediation and its effective methods in patients with early schizophrenia. Methods: Ninety-four outpatients (50 men, 44 women) with one of three conditions (schizophrenia in the critical period (within 5 years of the onset), chronic schizophrenia, or at-risk mental state for psychosis) were recruited.

Conference Presentations
A randomised clinical trial of a novel Audio-Visual Assisted Therapy Aid for Refractory auditory hallucinations (AVATAR therapy) Thomas Ward

Background: AVATAR therapy is a novel approach to working with distressing voices, which focuses on the relationship between voice-hearer and their voice. Specially developed computer technology enables each person to create an avatar of the entity (human or non-human) that they believe is talking to them. The person then dialogues with the 'avatar, which is controlled by the therapist to reflect a) verbatim voice content b) the persons understanding of their voice. During early stages the person asserts themselves over the avatar.

Conference Presentations
We are here for the long haul: Novel Social Media and Mobile Technologies for Long-term recovery in First Episode Psychosis (The Horyzons project) Mario Alvarez-Jimenez

Background: Early intervention services have demonstrated improved outcomes in first episode psychosis (FEP); however, recent evidence shows that treatment benefits may not be sustainable over time. Objectives: The aim of this study is to answer the important question of whether the clinical benefits of specialised FEP programmes can be extended into long-term improvements through the use of a world-first, online psychosocial intervention.

Conference Presentations
Non-remission of positive symptoms and functional recovery in first-episode psychosis Swapna Verma

Objective: The aim of the study was to examine the rates and significant predictors of non-remission of positive symptoms in FEP and to evaluate the impact of non-remission on functional recovery. Methods: All consecutive patients with FEP presenting to the Singapore Early Psychosis Intervention Programme (EPIP) from 2001 to 2008 were recruited for the study. We used a priori criteria to define non-remission i.e.

Conference Presentations
Economic evaluation of Early Intervention in Psychosis in comparison to Treatment as Usual Caragh Behan

Early intervention in psychosis (EIP) is an accepted policy internationally. It is important to evaluate whether policies are applicable within a local context. The aim of this study is to perform an economic evaluation of an EIP service in comparison to treatment as usual (TAU).

Conference Presentations
Neuroanatomy of Comorbid Affective Disorders in the Ultra-High Risk of Psychosis State Gemma Modinos

Background: Symptoms of depression and anxiety are often the primary complaint of the Ultra-High Risk of psychosis (UHR) patient rather than attenuated psychotic symptoms, with a significant impact on psychosocial and emotional functioning. Reasons for the high frequency of affective disorders such as depression and anxiety in people at UHR are uncertain.

Conference Presentations
Anterior Cingulate Cortex Abnormalities in Postpartum Psychosis. A structural MRI study. montserrat Fuste

Introduction: Postpartum Psychosis (PP) is the most severe psychiatric disorder associated with childbirth. The risk is very high in women with bipolar disorder. Unfortunately, the neurobiological basis of PP remains poorly understood and no previous study has evaluated brain structure in women at risk of, or with, PP. The aims of the study were: 1) Examine brain structural differences in women that develop PP episode compared to the ones that dont develop PP and healthy controls.

Conference Presentations
Translational psychiatric research focusing on microglia – Does microglial modulation prevent psychosis? Takahiro Kato

Neurons and synapses have long been the dominant focus of neuroscience, thus the pathophysiology of neuropsychiatric disorders including schizophrenia has come to be understood within the neuronal doctrine. Recently, glial functions have been gradually investigated, and increasing evidence has suggested that glial cells including astrocytes, oligodendrocytes and microglia perform important roles in various brain functions.

Conference Presentations
Idiopathic carbonyl stress in a subpopulation of schizophrenia Makotoi Ara

Evidence based on biological treatment and psychosocial support is essential to achieve and maintain a recovery for patients with schizophrenia. Studies have attempted to clarify the underlying disease mechanisms, however, the main cause and pathophysiology of schizophrenia remains unclear. Especially, heterogeneity in schizophrenia makes the search for molecular mechanisms much more difficult due to biochemical differences, variability across clinical symptoms, courses of illness, presence of risk factors and treatment responses.

Conference Presentations
Psychotic reactivity to daily life stress and the dopamine system: a study combining experience sampling and [18F]fallypride positron emission tomography. Inez Myin-Germeys

Background: Stressful life events increase the risk for psychosis and daily life stress drives moment-to-moment variation in psychotic intensity. Positron emission tomography (PET) studies suggest that prefrontal DAergic activity mediates the behavioral response to an experimental stressor. It is not known how alterations in this DAergic response, associated with psychosis, relate to real life stress responses in momentary assessment studies.

Conference Presentations

Pages