IEPA 2014

Title Poster First Author Abstract or summary Type
Cognitive pathway between trauma and psychosis Emmanuelle Peter

Cognitive models of psychosis suggest that (1) appraisals are key in determining the transition from benign anomalous experience to psychotic symptoms, and (2) trauma may be one of the predisposing factors to psychosis, which is increasingly supported by empirical evidence (Varese et al, 2012). However it remains unclear whether trauma predisposes to the development of anomalous experiences, or to the pathogenic appraisals which transform them into psychotic symptoms.

Conference Presentations
The role of childhood abuse in the course and outcome of psychotic disorders over 10 years. Helen L Fisher

Increasing evidence suggests that exposure to traumatic events in childhood is linked to the emergence of psychotic disorders in adulthood. However, the impact of childhood trauma on the longer-term outcomes of psychosis is largely unknown. Initial research suggests that early trauma is associated with worse clinical and functional outcomes amongst those with psychotic disorders. However, these studies suffer from a range of methodological limitations.

Conference Presentations
Long-term outcome following early dose-reduction of antipsychotics in remitted first episode psychosis Lex Wunderink

Objective Comparing 7-year outcome of early antipsychotic dose-reduction/discontinuation (DR) with maintenance treatment (MT) on remission, relapse and recovery in remitted first episode psychosis (FEP).Method FEP patients (N=128) symptomatically remitted for 6m during their first treatment year who completed an 18 months trial comparing MT and DR were followed-up at 7 years. Symptomatic remission criteria were adopted from Andreasen et al., functional remission criteria were based on a functioning scale. Recovery was defined as meeting both criteria sets.

Conference Presentations
The relation between antipsychotic medication history and ten-year outcome in first episode psychosis Ingrid Melle

ObjectiveAntipsychotic medication has significant clinical effect in reducing psychotic symptoms and preventing relapse in psychotic disorders. Many are however negative to long-term use due to side-effects and clinical experience indicates that some patients manage well without medication in the longer term. Methods281 patients with first-episode, schizophrenia spectrum disorders entered a medication algorithm advising 2 years continuous medication. Patients were followed from first week of treatment with re-evaluations after 3 months, 1, 2, 5 and 10 years.

Conference Presentations
Developmental trajectories and psychopathology in young relatives at risk for schizophrenia Matcheri S Keshavan

Objectives. A great deal of research has focused on identifying predictors and developing early interventions for individuals with psychotic disorders such as schizophrenia. While the relationships between early psychopathology, neurocognitive and social deficits and later emergence of psychosis have been studied for some time, the temporal evolution of psychopathology and its neurodevelopmental parallels in individuals at high risk (HR) for schizophrenia is less well characterized.

Conference Presentations
Cognitive change is related to brain loss in the early phases of schizophrenia Rene S Kahn

Background. There is consistent evidence for cognitive changes prior to the onset of psychosis in schizophrenia. Also, progressive brain changes during the course of the disease have consistently been shown, but it has not been studied whether the two phenomena are related.Method. A total of 78 first-episode schizophrenia patients and 113 age-matched healthy controls were tested twice with a three year interval. IQ and 1.5T sMRI were obtained at both time points.

Conference Presentations
Factors for Motivational Intervention of Exercise in Patients with Psychosis Edwin H. M. Lee

BackgroundPhysical activity has many well-known benefits including reduce the risk of cardiovascular disease, diabetes, obesity, hypertension, cancers and early death. Despite the fact that regular physical activity helps to improve functioning and reduce symptoms, the prevalence of physical activity remains low due to multiple biopsychosocial factors.

Conference Presentations
SHAPE (Supporting Health And Promoting Exercise) Project for Young People with Psychosis Jo Smith

Physical health problems are common in young people with psychosis who experience poor health and a significant reduction in life expectancy. This is mainly due to premature cardiovascular disease (CVD), underpinned by metabolic disorders like diabetes, and tobacco smoking. Moreover, the mortality gap compared to non-psychotic peers is widening. Yet in many UK EI services, physical health monitoring is not systematic and care plans fail to routinely address the physical health risks for young people with psychosis.

Conference Presentations
Early Lifestyle Intervention Attenuates Antipsychotic-Induced Weight Gain In First Episode Psychosis Jackie Curtis

Youth with first episode psychosis (FEP) receiving antipsychotic (AP) medications are at risk of obesity and metabolic syndrome. AP initiation induces rapid deterioration in metabolic health, with up to 77% experiencing clinically significant (>7%) weight-gain within 12 months(1,2). We aimed to determine whether a multidisciplinary, 12-week intervention could attenuate weight gain.

Conference Presentations
Characterizing and Operationalizing Clinical High-Risk for Bipolar Disorder: Description and Validation of The Bipolar Prodrome Symptom Interview and Scale-Prospective (BPSS-P) in a Psychiatric Sample and Healthy Controls Taishiro Kishimoto

Aims: To 1) summarize the current terminology, models and emerging criteria for risk for bipolar disorder (BD), and 2) present data on the validation of the first specific bipolar prodrome interview/rating scale.Methods: 1) Review of existing terminology, models and operational criteria for individuals considered at-risk for BD; 2) Interview study investigating the psychometric characteristics of the Bipolar Prodrome Symptom Interview and Scale-Prospective (BPSS-P), the first dedicated bipolar at-risk interview/rating scale.

Conference Presentations

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