IEPA 2014

Title Poster First Author Abstract or summary Type
Multisensory integration of emotional stimuli in first episode psychosis and ultra high risk states Huai-Hsuan Tseng

Background: Multisensory integration (MSI) is impaired in patients with schizophrenia and is associated with neurofunctional alterations in the posterior superior temporal sulcus (pSTS). However, MSI in first episode psychosis patients (FEP) and individuals at ultra-high risk (UHR) for psychosis remains unclear. We examined the neural correlates of MSI using congruent and incongruent audiovisual emotional stimuli in FEP patients, UHR, and healthy control subjects (HC). Methods: 20 HC, 15 UHR and 17 FEP were scanned using 1.5 T functional Magnetic Resonance Imaging during a MSI task.

Conference Presentations
Persistent Negative Symptoms in first episode psychosis: Predictors and outcomes at 10 year follow-up. Stephen F Austin

Introduction : Negative symptoms are a core component of schizophrenia, impact on outcomes and often are resistant to treatment. The goal of this study was to investigate the prevalence, baseline predictors and long term impact of persistent negative symptoms (PNS) within a large representative cohort of people with first episode psychosis. Method: The study had a prospective design. Patients recruited into the OPUS trial (1998-2000) with a first time diagnosis within the schizophrenia spectrum (F20-28) were included.

Conference Presentations
Clinical course and predictors of antipsychotic treatment resistance in a 10 year follow up first episode psychosis study Arsime Demjaha

Background It is unclear whether antipsychotic treatment resistance in schizophrenia manifests at the outset of illness, or becomes apparent over time. We examined this issue in a large cohort of first episode psychosis (FEP) patients followed up for 10-years. We hypothesised that treatment resistance would already be apparent at illness outset and characterized by a different oetiological profile, thus representing a distinct subtype of illness. Method The analytical cohort comprised 323 FEP patients who were studied at first contact and at 10-year follow up.

Conference Presentations
The fractional anisotropy of the white matter in an at-risk mental state for psychosis: the tract specific analysis Junichi Saito

Introduction: Examining the fractional anisotropy (FA) values as an indicator of integration of white matter in individuals with an at-risk mental state (ARMS) for psychosis is important to reveal the vulnerability factors and pathogenic mechanisms. Methods: Thirty-one right-handed ARMS patients were scanned using magnetic resonance imaging (MRI) to acquire diffusion tensor imaging (DTI) images at baseline and at 52 weeks. Sixteen right-handed healthy controls (HCs) underwent MRI scanning at baseline.

Conference Presentations
Effect of Dorsomedial Prefrontal GABA Levels on Brain Perfusion in People at Ultra High Risk for Psychosis Gemma Modinos

Background: Altered cortical _-aminobutyric acid (GABA)ergic function has been proposed to play a critical role in the dopamine elevations classically observed in psychosis. In addition, increased levels of brain perfusion have been largely documented in patients with psychosis, thought to arise from such neurochemical alterations. Whether GABAergic function is related to brain perfusion before the onset of psychotic disorder is unknown.

Conference Presentations
Multimodal Imaging in Individuals at Clinical High Risk for Psychosis Tiziano Colibazzi

The development of psychotic illness is preceded by a long phase characterized by attenuated or brief psychotic symptoms as well as functional decline. We have collected imaging data in multiple modalities in a cohort consisting of 61 subjects deemed at Clinical High Risk (CHR) for psychosis as well as 55 age- and gender matched healthy controls. Analyses of baseline functional data during performance of a task engaging cognitive control (Simon task) revealed in CHR subjects elevated functional activity during trials not associated with conflict.

Conference Presentations
Sensory gating, cannabis use and the risk of psychosis Toby Winton-Brown

Sensorimotor gating, measured as the modification of eye blink startle reflexes to acoustic stimuli by quieter preceding stimuli, is altered in those with psychosis their relatives and those at high clinical risk (UHR) for psychosis. Alterations have also been shown in cannabis users, albeit to a lesser extent, and cannabis is a known risk factor for the onset of psychosis in clinically and genetically susceptible individuals.

Conference Presentations
Effects of cannabis use on physical health in first-episode psychosis patients-IMPACT-PUMP Study Zerrin Atakan

Background: Cannabis use among first-episode psychosis (FEP) patients is significantly higher than in the general population and is associated with a poorer psychiatric prognosis. Little is known however about the physical health consequences of its use. Patients with psychoses are also known to have worse health outcomes. As part of the IMPACT study (improving physical health and reducing substance use of people with psychosis) we have investigated the physical health consequences of cannabis use on FEP patients.

Conference Presentations
Does cannabis really influence first episode psychosis outcome negatively? Amal Abdel-Baki

Background: Different studies have concluded that cannabis use disorders (CUD) influenced negatively outcomes in first-episode psychosis (FEP). However, it is rarely mentioned if those cannabis users were also misusing other substances. Our study examined the specific impact of different SUDs (alcohol, cannabis, psychostimulants) on symptoms, social functioning and service utilization. Methodology: a prospective longitudinal of 2 years follow-up of 176 FEP between 18 to 30 years old, admitted to early psychosis programs in Montreal.

Conference Presentations
Studying Heart Arrhythmias in Relation to Psychosis (SHARP). Increased prevalence of suspect Brugada ECG in recent onset schizophrenia. Arjen Sutterland

Introduction: Schizophrenia is associated with an increased risk of sudden cardiac death, traditionally attributed to prolonged QTc interval and cardiovascular risk factors such as metabolic syndrome. However, defective ion channels are also implicated in schizophrenia. This applies as well for Brugada syndrome (BrS), a rare hereditary cardiac disorder associated with an increased risk of cardiac arrhythmias, which can been provoked by various drugs, including psychotropic.

Conference Presentations

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