IEPA 2012

Title Poster First Author Abstract or summary Type
The duration of untreated psychosis in people referred to English early intervention services. Max Marshall

In line with international consensus statements, Early Intervention Services in England were set up with the aim of reducing the duration of untreated psychosis to a median of three months. We will examine whether three months is indeed the cut-off point after which the benefits of early treatment are limited, using data from 1027 service users with first episode psychosis recruited to the National Eden study.

Conference Presentations
Excess Mortality, Causes Of Death And Life Expectancy In Main Groups Of Patients With Recent Onset Of Mental Disorders In 2000-2006 In Denmark, Finland And Sweden. Merete Nordentoft

Objective: To investigate the excess mortality in different diagnostic categories due to suicide and other external causes of death, and due to specific causes in connection with diseases and medical conditions. Method: In longitudinal national psychiatric case registers from Denmark, Sweden and Finland, a cohort of 277,210 recent-onset patients, who at least once during the period 2000 to 2006 were admitted due to a psychiatric disorder, were followed in national cause of death registers until death or the end of 2006.

Conference Presentations
Does individual placement and support compensate for neurocognitive deficit in first-episode psychosis? Kelly A Allott

Neurocognitive deficit, a hallmark of psychotic disorder, is associated with poorer vocational outcomes. Individual Placement and Support (IPS) is effective at improving vocational outcomes for people with psychosis. It has been proposed that IPS may function to compensate for neurocognitive deficits. This study will test the hypothesis that IPS compensates for the neurocognitive difficulties experienced by people with first-episode psychosis (FEP).

Conference Presentations
Time Changes In Cannabis Use In A Cohort Of Patients With First Episode Psychosis And Association With Clinical And Social Outcome. A Five-Year Follow-Up Of The Opus Cohort Merete Nordentoft

The aim was to assess whether abuse of cannabis in patients with first episode psychosis influences the clinical and social outcome. Methods: A total of 547 patients with first episode schizophrenia spectrum disorder were included in the OPUS trial, and 301 patients participated in the five year follow-up. Information on use of cannabis, clinical and social factors and service use was collected at entry and after five years from clinical interviews with SCAN, SAPS and SANS.

Conference Presentations
Interactions Between Bdnf Val66met Gene Polymorphism, Childhood Adverse Events And Brain Volume Changes In Schizophrenia And Bipolar Disorder Monica Aas

Background: Brain derived neurotrophic factor BDNF is important for brain development and plasticity, and here we tested if the functional BDNF Val66Met polymorphism interacts with childhood adverse events associated with brain abnormalities in patients with schizophrenia and bipolar disorder. Method: 106 Caucasians with broad DSM-IV schizophrenia spectrum or bipolar disorder (mean±age: 32.67±10.85; gender: 48.6% males) were consecutively recruited to the Thematically Organized Psychosis (TOP) Study.

Conference Presentations
Progressive Brain Change Associated With Persistent Negative Symptoms: A Longitudinal Study Of Non Affective First Episode Psychosis Martin Lepage

Objectives: Clinically significant persistent negative symptoms (PNS) represent an unmet therapeutic need in a significant proportion of patients with a first episode of non-affective psychosis (FEP). Therefore a better understanding of the pathophysiology of PNS in first-episode patients could help identify more target-specific treatments for those affected. Using a longitudinal voxel-based morphometry (VBM) analysis, we set out to determine if progressive changes in grey matter were evident between PNS and non-PNS patients following admission to a specialized program.

Conference Presentations
Blunted cortisol awakening response in men with first-episode psychosis: relationship to parental bonding Marita Pruessner

Early life adversity has been associated with an increased risk for the development of mental health problems, including psychotic disorders, perhaps mediated by dysregulation of the Hypothalamic Pituitary Adrenal (HPA) axis. Aim of the present study was to confirm our previous finding of an attenuated cortisol awakening response (CAR) in men with first episode psychosis (FEP) and to explore a possible link between a blunted CAR and early adversity as indicated by perceived parental bonding.

Conference Presentations
Efficacy of Risperidone Long-Acting injection in the first year of Schizophrenia: Relapse prevention and symptom reduction Kenneth Subotnik

Not Available

Conference Presentations
A Multi-Centre, Randomised Controlled Trial Of A Group Psychological Intervention For Psychosis With Comorbid Cannabis Dependence Over The Early Course Of Illness Kevin Madigan

Background: Patients who experience the onset of psychotic illness with a comorbid diagnosis of cannabis dependence experience poor clinical outcomes. Few studies have identified interventions that reduce cannabis use and improve clinical outcome amongst this population. Aims We undertook a multi-centre, randomised controlled trial of a group psychological intervention for psychosis with comorbid cannabis dependence to establish any effect to reduce cannabis use and improve symptoms, global functioning, insight, attitudes to treatment and subjective quality of life.

Conference Presentations
Remission, Relapse And Recovery Following Early Guided Discontinuation Of Antipsychotics Vs. Maintenance Treatment In FEP: Outcome At 7 Years Follow-Up. Lex Wundererink

Objective: Comparing 7-year outcome of early antipsychotic discontinuation strategy on remission, relapse and recovery in remitted first episode psychosis (FEP). Method FEP patients (N=128) symptomatically remitted for 6m during their first treatment year who completed an 18 months trial comparing maintenance treatment (MT) and guided discontinuation (GD) were followed-up at 7 years. Symptomatic remission criteria were adopted from Andreasen et al., functional remission criteria were based on a functioning scale. Recovery was defined as meeting both criteria sets.

Conference Presentations

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